1) Wawa. Wawa is a convenience store which I'm pretty sure only exists in PA, NJ and DE (correct me if I'm wrong). If you ever have the good fortune to come across one in the course of a long drive, take full advantage. There is fresh fruit, hot sandwiches, cheap gas, and even milkshakes. Joe is pictured here anticipating his made-to-order sandwich from this high-tech touch screen.
2) Cracker Barrel. The Wood Bros taught me the magic of Cracker Barrel. It's a ubiquitous restaurant chain where you can sit down, order some vegetables, and have a non-fried meal by a roaring hearth. You can even rent audiobooks on CD, and return them to any other Cracker Barrel location.
3) Parkways are better than interstates. Especially in New York, and especially in the autumn. They even have pretty names like Palisades, Merrit, and Hutchinson.
4) Music. Driving music should be aggressively happy, or feel-good in a keeps-you-awake way. I recommend Elvis Costello, Aretha Franklin, The Beatles, or early Ella Fitzgerald. I DO NOT recommend Iron & Wine, Miles Davis, or Radiohead. You will love them right to sleep.